About 50 people were transported from the scene with injuries, according to the Lexington County Sheriff’s Office.
The collision occurred about 2:35 a.m. in Cayce, S.C., near Charleston Highway and Pine Ridge Road, authorities said.
The Amtrak train was No. 91, traveling between New York and Miami. The Amtrak train’s lead engine derailed, as did some passenger cars, an Amtrak statement said.
The passenger train had eight crew members and approximately 139 passengers aboard.
No immediate information was available about the CSX train.
South Carolina’s Red Cross chapter tweeted that emergency res ponders were at the scene.
Online posts referred to “walking wounded” passengers seen walking along the tracks.
Authorities said a news conference would be held at 6:30 a.m. EST.